Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

Y Li, W Song, Y Tong, X Zhang, J Zhao, X Gao… - Journal of …, 2021 - Springer
Background The NLRP3-mediated pyroptosis, which could be regulated by miRNA-27a, is a
key player in the development of depression. Isoliquiritin is a phenolic flavonoid compound …

The role of IL-17-producing cells in cutaneous fungal infections

Y Sawada, A Setoyama, Y Sakuragi… - International Journal of …, 2021 - mdpi.com
The skin is the outermost layer of the body and is exposed to many environmental stimuli,
which cause various inflammatory immune responses in the skin. Among them, fungi are …

Immune sensing and potential immunotherapeutic approaches to control chromoblastomycosis

LCD Breda, IG Menezes, LNM Paulo, SR de Almeida - Journal of Fungi, 2020 - mdpi.com
Chromoblastomycosis (CBM) is a neglected, chronic, and progressive subcutaneous
mycosis caused by different species of fungi from the Herpotrichiellaceae family. CBM …

Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

RJA de Castro, CL Marina, A Sturny-Leclère… - PLoS …, 2023 - journals.plos.org
Macrophages play a key role in disseminated cryptococcosis, a deadly fungal disease
caused by Cryptococcus neoformans. This opportunistic infection can arise following the …

[HTML][HTML] Pathogenicity and Growth Conditions Modulate Fonsecaea Extracellular Vesicles' Ability to Interact With Macrophages

LO Las-Casas, CLF Marina, RJA de Castro… - Frontiers in Cellular …, 2022 - frontiersin.org
Chromoblastomycosis (CBM) is a chronic cutaneous and subcutaneous mycosis caused by
black, dimorphic, and filamentous fungi of the Dematiaceae family, such as species of the …

Cryptococcus neoformans Secretes Small Molecules That Inhibit IL‐1β Inflammasome‐Dependent Secretion

PH Bürgel, CL Marina, PHV Saavedra… - Mediators of …, 2020 - Wiley Online Library
Cryptococcus neoformans is an encapsulated yeast that causes disease mainly in
immunosuppressed hosts. It is considered a facultative intracellular pathogen because of its …

[HTML][HTML] Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th17 activity, whereas Th1 response, aided by Treg cells, is crucial for …

IM Siqueira, M Wüthrich, M Li, H Wang… - PLoS Neglected …, 2020 - journals.plos.org
Chromoblastomycosis (CBM) is a chronic worldwide subcutaneous mycosis, caused by
several dimorphic, pigmented dematiaceous fungi. It is difficult to treat patients with the …

Fonsecaea pedrosoi Conidia and Hyphae Activate Neutrophils Distinctly: Requirement of TLR-2 and TLR-4 in Neutrophil Effector Functions

LCD Breda, CNS Breda, JRF de Almeida… - Frontiers in …, 2020 - frontiersin.org
Chromoblastomycosis is a chronic and progressive subcutaneous mycosis caused mainly
by the fungus Fonsecaea pedrosoi. The infection is characterized by erythematous papules …

[HTML][HTML] The intratumor microbiome varies by geographical location and anatomical site in head and neck squamous cell carcinoma

R Yalamarty, S Magesh, D John, J Chakladar… - Current Problems in …, 2024 - Elsevier
Abstract Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly heterogeneous
cancer that is characterized by distinct phenotypes based on anatomical site and etiological …

Comparison of the antifungal activity of the pyrimidine analogs flucytosine and carmofur against human-pathogenic dematiaceous fungi

RA Coelho, F Almeida-Silva… - Medical …, 2024 - academic.oup.com
Chromoblastomycosis (CBM) and pheohyphomycosis (PHM) are the most common
implantation mycoses caused by dematiaceous fungi. In the past, flucytosine (5-FC) has …