Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of
which cannot be easily classified into simple (eg, deletion) or complex (eg, chromothripsis) …

The BLAST programs are widely used tools for searching protein and DNA databases for
sequence similarities. For protein comparisons, a variety of definitional, algorithmic and …

A large number of tiny noncoding RNAs have been cloned and named microRNAs (miRs).
Recently, we have reported that miR-15a and miR-16a, located at 13q14, are frequently …

A central aim of cancer research has been to identify the mutated genes that are causally
implicated in oncogenesis ('cancer genes'). After two decades of searching, how many have …

Ever since initial suggestions that instability at common fragile sites (CFSs) could be
responsible for chromosome rearrangements in cancers, CFSs and associated genes have …

Background Variation in the human fecal microbiota has previously been associated with
body mass index (BMI). Although obesity is a global health burden, the accumulation of …

Morpholino phosphorodiamidate antisense oligonucleotides (MOs) and short interfering
RNAs (siRNAs) are commonly used platforms to study gene function by sequence-specific …

Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …