Discovery chemists routinely identify purpose-tailored molecules through an iterative
structural optimization approach, but the preparation of each successive candidate in a …

In this review the reactivity of the bio-based platform compounds D-sorbitol and isosorbide
with green reagents and solvent dimethyl carbonate (DMC) is reported. Dehydration of D …

A red-light-mediated nPr-DMQA+-catalyzed cascade intramolecular trifluoromethylation and
dearomatization of indole derivatives with Umemoto's reagent has been developed. This …

This report describes a general method for the one‐pot direct N‐acylation of N‐heterocycles
using our previously developed 4‐(N, N‐dimethylamino) pyridine N‐oxide (DMAPO)/di‐tert …

In contrast to the considerable progress in the development of methodologies for amide
bond formation in amines, the development of direct N‐acylation of less nucleophilic N …

We report a mild superbase-catalyzed and nitrogen-selective carboxylation of N-heteroaryls,
with subsequent alkylation enabling the synthesis of drug-like O-alkyl carbamates in good …

A total synthesis of (−)-strempeliopine is disclosed that enlists a powerful SmI2-mediated
and BF3· OEt2-initiated dearomative transannular radical cyclization onto an indole by an N …

The chemical synthesis of N-acyl indoles is hindered by the poor nucleophilicity of indolic
nitrogen, necessitating the use of strongly basic reaction conditions that encumber …

Chemoselective transformations are a cornerstone of efficient organic synthesis; however,
achieving this goal for even simple transformations, such as acylation reactions, is often a …

A catalytic amount of a nitrogen bicyclic base, ie, DABCO, DBU or TBD, is effective for the
one-pot synthesis of heterocycles from 1, 4-, 1, 5-diols and 1, 4-bifunctional compounds via …