Synthesis of Phosphorodiamidate Oligonucleotide Dimers
J Albaneze-Walker, G Urbanietz… - The Journal of …, 2022 - ACS Publications
Azido nucleosides couple with phosphoramidites via an initial iminophosphorane, which
eliminates acrylonitrile to generate the coupled dimer P (V) product. The vulnerable …
eliminates acrylonitrile to generate the coupled dimer P (V) product. The vulnerable …
Obtaining symmetric and asymmetric bisphosphoramidates and bisphosphoramidothioates by a single step multicomponent reaction
A Zamudio-Medina, N Pérez-Hernández… - … , Sulfur, and Silicon …, 2021 - Taylor & Francis
We present a new single-step multicomponent reaction strategy for the synthesis of
symmetric and (novel) asymmetric bisphosphoramidate and bisphosphoramidothioate …
symmetric and (novel) asymmetric bisphosphoramidate and bisphosphoramidothioate …