When the Going Gets Tough, the Tough Get Going Life in the microbial world is no picnic.
Hard molecular rain falls incessantly from all sides, nutrients are scarce and unpredictable …

Approximately 50 genes that code for sequences responsible for processing sensory cues
and the assembly and operation of the flagella allow bacteria to respond to stimuli in their …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Summary The Bcl-2 relative Bak is thought to drive apoptosis by forming homo-oligomers
that permeabilize mitochondria, but how it is activated and oligomerizes is unclear. To clarify …

Publisher Summary The functional properties of ion channels, such as gating, ion selectivity,
single-channel conductance, multi-ion occupancy, transient blocking, desensitization, and …

In order to understand the structural bases of ion conduction, ion selectivity, and gating in
the nicotinic acetylcholine receptor, mutagenesis and covalent modification were combined …

Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the
necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key …

Voltage-activated K+ channels are integral membrane proteins that open or close a K+-
selective pore in response to changes in transmembrane voltage. Although the S4 region of …

With prolonged stimulation, voltage-activated K+ channels close by a gating process called
inactivation. This inactivation gating can occur by two distinct molecular mechanisms: N …

Substitution of a cysteine in the extracellular mouth of the pore of the Shaker-delta K+
channel permits allosteric inhibition of the channel by Zn2+ or Cd2+ ions at micromolar …