Targeting the PI3K/AKT/mTOR signaling pathway in lung cancer: an update regarding potential drugs and natural products
Iksen, S Pothongsrisit, V Pongrakhananon - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …
high incidence, the clinical management of the disease remains a major challenge. Several …
Novel roles of phosphoinositides in signaling, lipid transport, and disease
GRV Hammond, JE Burke - Current Opinion in Cell Biology, 2020 - Elsevier
Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …
The membrane surface as a platform that organizes cellular and biochemical processes
Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …
and organelles. In addition, their surfaces actively participate in biochemical reaction …
A critical evaluation of protein kinase regulation by activation loop autophosphorylation
R Reinhardt, TA Leonard - Elife, 2023 - elifesciences.org
Phosphorylation of proteins is a ubiquitous mechanism of regulating their function,
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …
localization, or activity. Protein kinases, enzymes that use ATP to phosphorylate protein …
Akt-ing up just about everywhere: compartment-specific Akt activation and function in receptor tyrosine kinase signaling
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions,
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
including survival, growth, metabolism, migration, and differentiation. Receptor tyrosine …
The 3.2-Å resolution structure of human mTORC2
A Scaiola, F Mangia, S Imseng, D Boehringer… - Science …, 2020 - science.org
The protein kinase mammalian target of rapamycin (mTOR) is the central regulator of cell
growth. Aberrant mTOR signaling is linked to cancer, diabetes, and neurological disorders …
growth. Aberrant mTOR signaling is linked to cancer, diabetes, and neurological disorders …
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation
phosphoinositide-dependent kinase 1 (PDK1) is an essential serine/threonine protein
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …
kinase, which plays a crucial role in cell growth and proliferation. It is often referred to as a …
Class I phosphoinositide 3-kinase (PI3K) regulatory subunits and their roles in signaling and disease
MK Rathinaswamy, JE Burke - Advances in Biological Regulation, 2020 - Elsevier
The Class I phosphoinositide 3-kinases (PI3Ks) are a group of heterodimeric lipid kinases
that regulate crucial cellular processes including proliferation, survival, growth, and …
that regulate crucial cellular processes including proliferation, survival, growth, and …
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation
L Truebestein, H Hornegger… - Proceedings of the …, 2021 - National Acad Sciences
The protein kinase Akt is one of the primary effectors of growth factor signaling in the cell. Akt
responds specifically to the lipid second messengers phosphatidylinositol-3, 4, 5 …
responds specifically to the lipid second messengers phosphatidylinositol-3, 4, 5 …
An optogenetic-phosphoproteomic study reveals dynamic Akt1 signaling profiles in endothelial cells
The serine/threonine kinase AKT is a central node in cell signaling. While aberrant AKT
activation underlies the development of a variety of human diseases, how different patterns …
activation underlies the development of a variety of human diseases, how different patterns …