Validation of biomarkers of aging

M Moqri, C Herzog, JR Poganik, K Ying, JN Justice… - Nature Medicine, 2024 - nature.com
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …

[HTML][HTML] Promises and challenges of populational proteomics in health and disease

BB Sun, K Suhre, BW Gibson - Molecular & Cellular Proteomics, 2024 - Elsevier
Advances in proteomic assay technologies has significantly increased coverage and
throughput, enabling recent increases in the number of large-scale population-based …

Plasma proteomic profiles of UK Biobank participants with multiple sclerosis

BM Jacobs, N Vickaryous, G Giovannoni… - Annals of Clinical …, 2024 - Wiley Online Library
Objective We aimed to describe plasma protein biomarkers of multiple sclerosis risk and to
explore protein biomarkers of disease severity using radiological outcome measures …

Epigenetic contributions to clinical risk prediction of cardiovascular disease

AD Chybowska, DA Gadd, Y Cheng… - Circulation: Genomic …, 2024 - Am Heart Assoc
BACKGROUND: Cardiovascular disease (CVD) is among the leading causes of death
worldwide. The discovery of new omics biomarkers could help to improve risk stratification …

[HTML][HTML] Proteomic aging clock (PAC) predicts age-related outcomes in middle-aged and older adults

CL Kuo, Z Chen, P Liu, LC Pilling, JL Atkins… - medRxiv, 2023 - ncbi.nlm.nih.gov
Background Beyond mere prognostication, optimal biomarkers of aging provide insights into
qualitative and quantitative features of biological aging and might therefore offer useful …

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

DA Gadd, HM Smith, D Mullin, O Chybowska… - medRxiv, 2023 - medrxiv.org
Background Plasma growth differentiation factor 15 (GDF15) and N-terminal pro-B-type
natriuretic peptide (NT-proBNP) are cardiovascular biomarkers that associate with a range …

Serum proteomic profiles of UK Biobank participants with Multiple Sclerosis

BM Jacobs, N Vickaryous, G Giovannoni, S Waters… - medRxiv, 2023 - medrxiv.org
Discovery of serum protein biomarkers for Multiple Sclerosis risk and severity could shed
light on pathophysiological mechanisms, suggest new drug targets, enhance the speed of …

[HTML][HTML] An interactive atlas of genomic, proteomic, and metabolomic biomarkers promotes the potential of proteins to predict complex diseases

M Benson, M Smelik, X Li, J Loscalzo, O Sysoev… - Research …, 2024 - ncbi.nlm.nih.gov
Multiomics analyses have identified multiple potential biomarkers of the incidence and
prevalence of complex diseases. However, it is not known which type of biomarker is optimal …