Validation of biomarkers of aging
The search for biomarkers that quantify biological aging (particularly 'omic'-based
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
biomarkers) has intensified in recent years. Such biomarkers could predict aging-related …
Proteomic signatures improve risk prediction for common and rare diseases
J Carrasco-Zanini, M Pietzner, J Davitte, P Surendran… - Nature medicine, 2024 - nature.com
For many diseases there are delays in diagnosis due to a lack of objective biomarkers for
disease onset. Here, in 41,931 individuals from the United Kingdom Biobank Pharma …
disease onset. Here, in 41,931 individuals from the United Kingdom Biobank Pharma …
Proteomic aging clock (PAC) predicts age‐related outcomes in middle‐aged and older adults
Beyond mere prognostication, optimal biomarkers of aging provide insights into qualitative
and quantitative features of biological aging and might, therefore, offer useful information for …
and quantitative features of biological aging and might, therefore, offer useful information for …
[HTML][HTML] Promises and challenges of populational proteomics in health and disease
Advances in proteomic assay technologies has significantly increased coverage and
throughput, enabling recent increases in the number of large-scale population-based …
throughput, enabling recent increases in the number of large-scale population-based …
Cardiovascular risk prediction using metabolomic biomarkers and polygenic risk scores: A cohort study and modelling analyses
Metabolomic platforms using nuclear magnetic resonance (NMR) spectroscopy can now
rapidly quantify many circulating metabolites which are potential biomarkers of …
rapidly quantify many circulating metabolites which are potential biomarkers of …
DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain
Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type
natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range …
natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range …
Proteomic analyses in diverse populations improved risk prediction and identified new drug targets for type 2 diabetes
P Yao, A Iona, A Pozarickij, S Said, N Wright… - Diabetes …, 2024 - Am Diabetes Assoc
OBJECTIVE Integrated analyses of plasma proteomics and genetic data in prospective
studies can help assess the causal relevance of proteins, improve risk prediction, and …
studies can help assess the causal relevance of proteins, improve risk prediction, and …
Plasma proteomic profiles of UK Biobank participants with multiple sclerosis
BM Jacobs, N Vickaryous, G Giovannoni… - Annals of Clinical …, 2024 - Wiley Online Library
Objective We aimed to describe plasma protein biomarkers of multiple sclerosis risk and to
explore protein biomarkers of disease severity using radiological outcome measures …
explore protein biomarkers of disease severity using radiological outcome measures …
Unveiling Novel Protein Biomarkers for Psoriasis Through Integrated Analysis of Human Plasma Proteomics and Mendelian Randomization
Background Current pharmacological treatments for psoriasis are generally non-specific
and have significant limitations, particularly in the realm of targeted biologic therapies. There …
and have significant limitations, particularly in the realm of targeted biologic therapies. There …
Epigenetic contributions to clinical risk prediction of cardiovascular disease
AD Chybowska, DA Gadd, Y Cheng… - Circulation: Genomic …, 2024 - Am Heart Assoc
BACKGROUND: Cardiovascular disease (CVD) is among the leading causes of death
worldwide. The discovery of new omics biomarkers could help to improve risk stratification …
worldwide. The discovery of new omics biomarkers could help to improve risk stratification …