Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Tumor progression depends on sequential events, including a switch to the angiogenic
phenotype (ie initial recruitment of blood vessels). Failure of a microscopic tumor to …

Increases in the number of circulating endothelial cells (CECs) and progenitors (CEPs) have
been reported in various pathological conditions including cancer. Preclinical studies have …

The formation of distant metastasis is the main cause of morbidity and mortality in patients
with cancer. The aim of this article is to review recent advances in molecular and clinical …

Abstract Development of antiangiogenic therapies would be significantly facilitated by
quantitative surrogate pharmacodynamic markers. Circulating peripheral blood endothelial …

Cancer, a proliferative disease hallmarked by abnormal cell growth and spread, is largely
dependent on tumor neoangiogenesis, with evidence of vascular endothelial dysfunction …

Endostatin, a potent inhibitor of endothelial cell proliferation, migration, angiogenesis and
tumor growth, is proteolytically cleaved from the C-terminal noncollagenous NC1 domain of …

Background—Recent data have indicated that estradiol can modulate the kinetics of
endothelial progenitor cells (EPCs) via endothelial nitric oxide synthase (eNOS)–dependent …

The book shows how mathematical and computational models can be used to study cancer
biology. It introduces the concept of mathematical modeling and then applies it to a variety of …

Collagen XVIII is a heparan sulphate proteoglycan which is expressed ubiquitously in
different basement membranes throughout the body. Its C-terminal fragment, endostatin, has …