Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded
by PTPN11), promotes developmental disorders and several malignancies by varying …

The Rho-family of small GTPases are biological molecular switches that are best known for
their regulation of the actin cytoskeleton. Through their activation and stimulation of …

Activated Cdc42-associated kinase 1 (ACK1/TNK2) is a nonreceptor tyrosine kinase with a
unique structure. It not only can act as an activated transmembrane effector of receptor …

Ripk3-mediated cellular apoptosis is a major contributor to the pathogenesis of myocardial
ischemia reperfusion (IR) injury. However, the mechanisms by which Ripk3 influences …

The challenge of rapid macromolecular synthesis enforces the energy-hungry cancer cell
mitochondria to switch their metabolic phenotypes, accomplished by activation of oncogenic …

Androgen receptor (AR) signaling continues to play a dominant role in all stages of prostate
cancer, including castration-resistant prostate cancers (CRPC) that have developed …

Resistance to second-generation androgen receptor (AR) antagonists such as enzalutamide
is an inevitable consequence in patients with castration-resistant prostate cancer (CRPC) …

The antitumor effect of prostaglandin D2 (PGD2) on gastric cancer (GC) has been known for
decades. However, the mechanism of PGD2's control of GC growth is unclear. Cancer stem …

Purpose: Androgen receptor (AR) antagonism is exacerbated by HOXB13 in castration-
resistant prostate cancers (CRPC). However, it is unclear when and how HOXB13 primes …

Purpose We set out to determine whether clinically tested epigenetic drugs against class I
histone deacetylases (HDACs) affect hallmarks of the metastatic process. Methods We …