1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …

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comprehensive source on medicinal chemistry and drug discovery and development. This …

Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

Catalytic asymmetric N‐alkylation of indoles and carbazoles represents a family of important
but underdeveloped reactions. Herein, we describe a new organocatalytic strategy in which …

In the present study we have investigated whether pharmacophore models may account for
the activity and selectivity of the known cyclooxygenase-2 (COX-2) selective inhibitors of the …

Phospholipases A2 (PLA2) are a diverse group of enzymes that hydrolyze membrane
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …

Abstract Phospholipase A 2 (PLA 2) enzymes are involved in various inflammatory
pathological conditions including arthritis, cardiovascular and autoimmune diseases. The …