Genetics of generalized anxiety disorder and related traits

MG Gottschalk, K Domschke - Dialogues in clinical neuroscience, 2017 - Taylor & Francis
This review serves as a systematic guide to the genetics of generalized anxiety disorder
(GAD) and further focuses on anxiety-relevant endophenotypes, such as pathological worry …

Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans

M Shimada‐Sugimoto, T Otowa… - Psychiatry and clinical …, 2015 - Wiley Online Library
This review provides a broad overview of the state of research in the genetics of anxiety
disorders (AD). Genetic epidemiological studies report a moderate level of familial …

Candidate genes in panic disorder: meta-analyses of 23 common variants in major anxiogenic pathways

AS Howe, HN Buttenschøn, A Bani-Fatemi… - Molecular …, 2016 - nature.com
The utilization of molecular genetics approaches in examination of panic disorder (PD) has
implicated several variants as potential susceptibility factors for panicogenesis. However …

Gene-environment interactions in psychiatry: recent evidence and clinical implications

RJ Musci, JL Augustinavicius, H Volk - Current psychiatry reports, 2019 - Springer
Abstract Purpose of Review We identify the recent evidence for gene-by-environment
interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as …

Attachment style and oxytocin receptor gene variation interact in influencing social anxiety

S Notzon, K Domschke, K Holitschke… - The World Journal of …, 2016 - Taylor & Francis
Objectives: Social anxiety has been suggested to be promoted by an insecure attachment
style. Oxytocin is discussed as a mediator of trust and social bonding as well as a modulator …

Extending the vulnerability–stress model of mental disorders: three-dimensional NPSR1× environment× coping interaction study in anxiety

MA Schiele, K Herzog, L Kollert, C Schartner… - The British Journal of …, 2020 - cambridge.org
BackgroundThe general understanding of the 'vulnerability–stress model'of mental disorders
neglects the modifying impact of resilience-increasing factors such as coping ability …

Role of the neuropeptide S system in emotionality, stress responsiveness and addiction-like behaviours in rodents: relevance to stress-related disorders

AM Tobinski, V Rappeneau - Pharmaceuticals, 2021 - mdpi.com
The neuropeptide S (NPS) and its receptor (NPSR1) have been extensively studied over the
last two decades for their roles in locomotion, arousal/wakefulness and anxiety-related and …

Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene

J Spada, C Sander, R Burkhardt, M Häntzsch, R Mergl… - PloS one, 2014 - journals.plos.org
Background The neuropeptide S receptor (NPSR1) and its ligand neuropeptide S (NPS)
have received increased attention in the last few years, as both establish a previously …

Neuropeptide S precursor knockout mice display memory and arousal deficits

X Liu, W Si, C Garau, K Jüngling… - European Journal of …, 2017 - Wiley Online Library
Activation of neuropeptide S (NPS) signaling has been found to produce arousal,
wakefulness, anxiolytic‐like behaviors, and enhanced memory formation. In order to further …

Neuronal expression of the human neuropeptide S receptor NPSR1 identifies NPS-induced calcium signaling pathways

F Erdmann, S Kügler, P Blaesse, MD Lange… - PloS one, 2015 - journals.plos.org
The neuropeptide S (NPS) system was discovered as a novel neurotransmitter system a
decade ago and has since been identified as a key player in the modulation of fear and …