Neuropeptides in dental pulp: the silent protagonists

J Caviedes-Bucheli, HR Muñoz… - Journal of …, 2008 - Elsevier
Dental pulp is a soft mesenchymal tissue densely innervated by afferent (sensory) fibers,
sympathetic fibers, and parasympathetic fibers. This complexity in pulp innervation has …

Neurological heterotopic ossification: current understanding and future directions

RD Brady, SR Shultz, SJ McDonald, TJ O'Brien - Bone, 2018 - Elsevier
Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue
following a neurological condition, of which the most common are brain and spinal cord …

Dental nerves: a neglected mediator of pulpitis

C Zhan, M Huang, X Yang, J Hou - International Endodontic …, 2021 - Wiley Online Library
As one of the most densely innervated tissues, the dental pulp contains abundant nerve
fibres, including sensory, sympathetic and parasympathetic nerve fibres. Studies in animal …

Peripheral mechanisms of dental pain: the role of substance P

P Sacerdote, L Levrini - Mediators of inflammation, 2012 - Wiley Online Library
Current evidence supports the central role of neuropeptides in the molecular mechanisms
underlying dental pain. In particular, substance P, a neuropeptide produced in neuron cell …

Osteocytes

LF Bonewald - Marcus and Feldman's Osteoporosis, 2021 - Elsevier
Osteocytes are defined as cells embedded in the mineralized bone matrix and compose
over 90%–95% of all bone cells. They are regularly dispersed throughout the mineralized …

Sensory neuropeptides are required for bone and cartilage homeostasis in a murine destabilization-induced osteoarthritis model

D Muschter, L Fleischhauer, S Taheri, AF Schilling… - Bone, 2020 - Elsevier
Numerous studies identified a role for the sensory neuropeptides substance P (SP) and
alpha calcitonin gene-related peptide (αCGRP) in osteoarthritis (OA) pain behavior …

[HTML][HTML] Neural regulations of the tumor microenvironment

AC Restaino, PD Vermeer - FASEB BioAdvances, 2022 - ncbi.nlm.nih.gov
The identification of nerves in the tumor microenvironment has ushered in a new area of
research in cancer biology. Numerous studies demonstrate the presence of various types of …

Calcitonin gene‑related peptide: A promising bridge between cancer development and cancer‑associated pain in oral squamous cell carcinoma

Y Zhang, C Lin, X Wang, T Ji - Oncology letters, 2020 - spandidos-publications.com
Nerves have been widely demonstrated to exert major effects in tumor‑associated
microenvironments. Due to the characteristic innervation of the oral cavity and the fact that …

Effect of experimentally induced occlusal trauma on substance P expression in human dental pulp and periodontal ligament

J Caviedes-Bucheli, MM Azuero-Holguin… - Journal of …, 2011 - Elsevier
INTRODUCTION: The purpose of this study was to quantify the effect of occlusal trauma
experimentally induced with occlusal interferences on substance P (SP) expression in …

5-Hydroxytryptamine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

R Andrade, NM Barnes, G Baxter… - IUPHAR/BPS Guide …, 2019 - journals.ed.ac.uk
HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors
[194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT 3 class …