This study describes the occurrence of renal failure among 1353 newly diagnosed cases of
multiple myeloma. Renal function was evaluated by serum creatinine concentration in 1353 …

How individual enzymes evolved is relatively well understood. However, individual enzymes
rarely confer a physiological advantage on their own. Judging by its current state, the …

Experimental structures are leveraged through multiple sequence alignments, or more
generally through homology-based inference (HBI), facilitating the transfer of information …

The OB-fold is found in all three kingdoms and is well represented in both sequence and
structural databases. The OB-fold is a five-stranded closed β barrel and the majority of OB …

Synonymous rare codons are considered to be sub-optimal for gene expression because
they are translated more slowly than common codons. Yet surprisingly, many protein coding …

Contemporary protein architectures can be regarded as molecular fossils, historical imprints
that mark important milestones in the history of life. Whereas sequences change at a …

Smut fungi are well-suited to investigate the ecology and evolution of plant pathogens, as
they are strictly biotrophic, yet cultivable on media. Here we report the genome sequence of …

Comparative analysis of numerous protein structures that have become available in the past
few years, combined with genome comparison, has yielded new insights into the evolution …

Abstract CATH version 3.3 (class, architecture, topology, homology) contains 128 688
domains, 2386 homologous superfamilies and 1233 fold groups, and reflects a major focus …

Background Transcription factors play the crucial rule of regulating gene expression and
influence almost all biological processes. Systematically identifying and annotating …