[HTML][HTML] The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

Promises and pitfalls of using high‐throughput sequencing for diet analysis

A Alberdi, O Aizpurua, K Bohmann… - Molecular ecology …, 2019 - Wiley Online Library
The application of high‐throughput sequencing‐based approaches to DNA extracted from
environmental samples such as gut contents and faeces has become a popular tool for …

[HTML][HTML] Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C Xie, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

[HTML][HTML] Snake venoms in drug discovery: Valuable therapeutic tools for life saving

T Mohamed Abd El-Aziz, AG Soares, JD Stockand - Toxins, 2019 - mdpi.com
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

[HTML][HTML] Polymorphic toxin systems: comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative …

D Zhang, RF de Souza, V Anantharaman, LM Iyer… - Biology direct, 2012 - Springer
Background Proteinaceous toxins are observed across all levels of inter-organismal and
intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin …

High-throughput proteomics and in vitro functional characterization of the 26 medically most important elapids and vipers from sub-Saharan Africa

GTT Nguyen, C O'Brien, Y Wouters, L Seneci… - …, 2022 - academic.oup.com
Venomous snakes are important parts of the ecosystem, and their behavior and evolution
have been shaped by their surrounding environments over the eons. This is reflected in their …

A current perspective on snake venom composition and constituent protein families

T Tasoulis, GK Isbister - Archives of toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …

Cytotoxicity of snake venom enzymatic toxins: phospholipase A2 and l-amino acid oxidase

JJ Hiu, MKK Yap - Biochemical society transactions, 2020 - portlandpress.com
The phospholipase A2 (PLA2) and l-amino acid oxidase (LAAO) are two major enzymes
found in the venoms from most snake species. These enzymes have been structurally and …

Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins

S Takeda, H Takeya, S Iwanaga - … et Biophysica Acta (BBA)-Proteins and …, 2012 - Elsevier
Metalloproteinases are among the most abundant toxins in many Viperidae venoms. Snake
venom metalloproteinases (SVMPs) are the primary factors responsible for hemorrhage and …

Snake venom: from deadly toxins to life-saving therapeutics

H Waheed, SF Moin… - Current medicinal …, 2017 - ingentaconnect.com
Snakes are fascinating creatures and have been residents of this planet well before ancient
humans dwelled the earth. Venomous snakes have been a figure of fear, and cause notable …