Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

JA Jiménez, MJ Zylka - Journal of neurodevelopmental disorders, 2021 - Springer
Research with rodents is crucial for expanding our understanding of genetic and
environmental risk factors for neurodevelopmental disorders (NDD). However, there is …

[HTML][HTML] Maternal immune activation in rodent models: A systematic review of neurodevelopmental changes in gene expression and epigenetic modulation in the …

RM Woods, JM Lorusso, HG Potter, JC Neill… - Neuroscience & …, 2021 - Elsevier
Maternal immune activation (mIA) during pregnancy is hypothesised to disrupt offspring
neurodevelopment and predispose offspring to neurodevelopmental disorders such as …

Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters

MC Catanese, LN Vandenberg - Endocrinology, 2017 - academic.oup.com
Estrogenic endocrine disrupting chemicals have been shown to disrupt maternal behavior in
rodents. We investigated the effects of an emerging xenoestrogen, bisphenol S (BPS), on …

[HTML][HTML] Maternal behaviours and adult offspring behavioural deficits are predicted by maternal TNFα concentration in a rat model of neurodevelopmental disorders

HG Potter, HM Kowash, RM Woods, G Revill… - Brain, Behavior, and …, 2023 - Elsevier
Exposure to inflammatory stressors during fetal development is a major risk factor for
neurodevelopmental disorders (NDDs) in adult offspring. Maternal immune activation (MIA) …

Statistical modeling with litter as a random effect in mixed models to manage “intralitter likeness”

MS Golub, CA Sobin - Neurotoxicology and Teratology, 2020 - Elsevier
Abstract “Intralitter likeness,” the possibility that the shared genetics and/or maternal
environment in multiparous species causes strong similarity for outcome variables in …

Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the …

EV Kozlova, MC Valdez, ME Denys, AE Bishay… - Archives of …, 2022 - Springer
Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic pollutants
(POPs) that are known neuroendocrine disrupting chemicals with adverse …

[HTML][HTML] Examining litter specific variability in mice and its impact on neurodevelopmental studies

V Valiquette, E Guma, L Cupo, D Gallino… - Neuroimage, 2023 - Elsevier
Our current understanding of litter variability in neurodevelopmental studies using mice may
limit translation of neuroscientific findings. Higher variance of measures across litters than …

Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice, and Molecular Mechanisms, in Vitro

R Chamorro-García, BM Shoucri… - Environmental …, 2018 - ehp.niehs.nih.gov
Background: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride
(PVC) plastics, in construction materials, and in medical devices. Previous animal studies …

Exposure to low doses of oxybenzone during perinatal development alters mammary gland morphology in male and female mice

K Matouskova, DJ Jerry, LN Vandenberg - Reproductive Toxicology, 2020 - Elsevier
Abstract Oxybenzone (benzophenone-3) is an ultraviolet radiation filter commonly used in
personal care products including sunscreens, textiles and inks, and food and beverage …

Maternal acrylamide exposure changes intestinal epithelium, immunolocalization of leptin and ghrelin and their receptors, and gut barrier in weaned offspring

S Muszyński, M Hułas-Stasiak, P Dobrowolski… - Scientific Reports, 2023 - nature.com
Acrylamide (ACR) is an amide formed as a byproduct in many heat-processed starchy-rich
foods. In utero ACR exposure has been associated with restricted fetal growth, but its effects …