Mechanical stress from haemodynamic perturbations or interventional manipulation of
epicardial coronary atherosclerotic plaques with inflammatory destabilization can release …

Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Preclinical large animal models of heart failure (HF) play a critical and expanding role in
translating basic science findings to the development and clinical approval of novel …

Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Until recently, epicardial coronary stenosis has been considered the primary outcome of
coronary heart disease, and clinical interventions have been dedicated primarily to the …

This study investigated how miR-136-5p partially affected cardiomyocyte pyroptosis in rats
with coronary microembolization (CME). The cardiac function and structure of rats with CME …

Fluorosis is a worldwide public health problem, and its adverse effects on the heart have
been confirmed by many studies. Abnormal myocardial contractions are often associated …

Congestive heart failure (CHF) has increased over the years, in part because of recent
progress in the management of chronic diseases, thus contributing to the maintenance of an …

Acute myocardial infarction continues to account for a growing burden of heart failure
worldwide. Despite existing therapies, new approaches for reducing the extent of damage …

The aim of the study was to develop a model of coronary microembolization (CME) in rats at
a lower cost. We developed a novel rat model without thoracotomy and ventilation under the …