[HTML][HTML] Fundamental aspects of solid dispersion technology for poorly soluble drugs

Y Huang, WG Dai - Acta Pharmaceutica Sinica B, 2014 - Elsevier
The solid dispersion has become an established solubilization technology for poorly water
soluble drugs. Since a solid dispersion is basically a drug–polymer two-component system …

[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers

J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

General synthesis of hierarchical sheet/plate-like M-BDC (M= Cu, Mn, Ni, and Zr) metal–organic frameworks for electrochemical non-enzymatic glucose sensing

G Gumilar, YV Kaneti, J Henzie, S Chatterjee, J Na… - Chemical …, 2020 - pubs.rsc.org
Two-dimensional metal–organic frameworks (2D MOFs) are an attractive platform to develop
new kinds of catalysts because of their structural tunability and large specific surface area …

Evaluation of amorphous solid dispersion properties using thermal analysis techniques

JA Baird, LS Taylor - Advanced drug delivery reviews, 2012 - Elsevier
Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

High-performance 3D printing of hydrogels by water-dispersible photoinitiator nanoparticles

AA Pawar, G Saada, I Cooperstein, L Larush… - Science …, 2016 - science.org
In the absence of water-soluble photoinitiators with high absorbance in the ultraviolet (UV)–
visible range, rapid three-dimensional (3D) printing of hydrogels for tissue engineering is …

Drug precipitation inhibitors in supersaturable formulations

S Xu, WG Dai - International journal of pharmaceutics, 2013 - Elsevier
Use of supersaturable formulations has been demonstrated as an effective approach to
improve solubility and oral absorption of poorly water-soluble compounds. In supersaturable …

Stability of amorphous pharmaceutical solids: crystal growth mechanisms and effect of polymer additives

Y Sun, L Zhu, T Wu, T Cai, EM Gunn, L Yu - The AAPS journal, 2012 - Springer
We review recent progress toward understanding and enhancing the stability of amorphous
pharmaceutical solids against crystallization. As organic liquids are cooled to become …

The implications of drug-polymer interactions on the physical stability of amorphous solid dispersions

M Bookwala, PLD Wildfong - Pharmaceutical Research, 2023 - Springer
Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance

Q Shi, H Chen, Y Wang, R Wang, J Xu, C Zhang - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

The revelation of glucose adsorption mechanisms on hierarchical metal–organic frameworks using a surface plasmon resonance sensor

G Gumilar, S Chowdhury, G Shukri, A Patah… - Journal of Materials …, 2023 - pubs.rsc.org
The gold layer on the surface plasmon resonance (SPR) sensor chip cannot detect small
molecules, such as glucose without the use of specific receptors. Metal–organic frameworks …