Apicomplexan parasites have complex life cycles, frequently split between different hosts
and reliant on rapid responses as the parasites react to changing environmental conditions …

Acidocalcisomes are organelles conserved during evolution and closely related to the so-
called volutin granules of bacteria and archaea, to the acidocalcisome-like vacuoles of …

In the apicomplexans, endocytosed cargos (eg, hemoglobin) are trafficked to a specialized
organelle for digestion. This follows a unique endocytotic process at the …

Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic
organelles in animals and plants to regulate numerous Ca2+-dependent events. Little is …

The Apicomplexa phylum includes a large group of obligate intracellular protozoan
parasites responsible for important diseases in humans and animals. Toxoplasma gondii is …

Iron is essential to cells as a cofactor in enzymes of respiration and replication, however
without correct storage, iron leads to the formation of dangerous oxygen radicals. In yeast …

Acidocalcisomes are organelles rich in polyphosphate and cations and acidified by proton
pumps. Although they have also been described in prokaryotes they have been better …

Pyrophosphatases (PPases) are enzymes that catalyze the hydrolysis of pyrophosphate
(PPi), a byproduct of the synthesis and degradation of diverse biomolecules. The …

Toxoplasma gondii belongs to the phylum Apicomplexa and is an important cause of
congenital disease and infection in immunocompromised patients. T. gondii shares several …

Inorganic pyrophosphatase (PPase) participates in energy cycle and plays a vital role in
hydrolysis of inorganic pyrophosphate (PPi) into inorganic phosphate (Pi). The aim of this …