Despite the persistent presence of medium-sized (seven-to nine-membered) scaffolds in
natural products and biologically active molecules, their asymmetric syntheses have always …

The organocatalytic asymmetric Morita–Baylis–Hillman (MBH) reaction produces a
significant carbon–carbon bond formation that involves the addition of α, β-unsaturated …

We disclose herein a highly diastereo-and enantioselective divergent synthesis of seven-
membered biaryl-bridged carbo-and oxacyclic frameworks by utilizing the catalytic ability of …

Simultaneous dearomatizing spirannulation of pyridinium salts is still in its infancy. Here, we
present an organized skeletal remodeling of designed pyridinium salts by utilizing an …

The organocatalytic asymmetric Morita–Baylis–Hillman (MBH) reaction of isatin derivatives
with various vinyl sulfones is disclosed. Chiral sulfone-containing 3-hydroxyoxindoles were …

A palladium-catalyzed ring-opening [3+ 2]-annulation of spirovinylcyclopropanyl oxindoles
with seven-membered cyclic N-sulfonylimines has been developed. A wide range of seven …

We disclose herein a chiral phosphoric-acid-catalyzed enantioselective addition reaction of
alcohols to fluoroalkylated biaryl 1, 3-oxoazepines, which furnished a wide range of bridged …

Chemoselectivity is an important issue frequently encountered while working over labile
precursors. Carbonyl compounds with a heteroatom at the β carbon are sensitive precursors …

Herein, we demonstrated a Pd-catalyzed cascade reaction that involves arylation, Trost–
Oppolzer type Alder ene reaction, and double bond isomerization using the 4-(2 …

We demonstrate the first phosphine-catalyzed intramolecular vinylogous aldol reaction
(IVAR) of α-substituted enones. This strategy provides access to various pentannulated …