Cancer is a leading cause of mortality responsible for an estimated 10 million deaths
worldwide in 2020, and its incidence has been rapidly growing over the last decades …

As a continuation of our endeavors in discovering metal-based drugs with cytotoxic and
antimetastatic activities, herein, we reported the syntheses of 11 new rhodium (III) …

Triple-negative breast cancer (TNBC) is a highly resistant, lethal, and metastatic sub-division
of breast carcinoma, characterized by the deficiency of estrogen receptor (ER), progesterone …

Abnormal activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome is
closely associated with a variety of inflammatory diseases. Herein, we describe the …

Human dihydroorotate dehydrogenase (h DHODH) is an attractive tumor target essential to
de novo pyrimidine biosynthesis. Novel potent h DHODH inhibitors with low toxicity are …

Oridonin (ORI) has been shown to inhibit tumor cell growth and proliferation in vitro, while its
optimum anti-tumor activity in vivo is limited due to the poor aqueous solubility and …

In this study, twenty-one novel 2, 4-diaminopyrimidine cinnamyl derivatives as inhibitors
targeting FAK were designed and synthesized based on the structure of TAE-226, and the …

Activating programmed cell death by delivering hydrogen sulfide (H 2 S) has emerged as a
promising strategy for tumor therapy. Oridonin serves as a lead compound for drug …

Targeted protein degradation using small molecules is an intriguing strategy for drug
development. The marine sesterterpene compound MHO7 had been reported to be a …

The rate-limiting serine biogenesis enzyme PHGDH is overexpressed in cancers. Both
serine withdrawal and genetic/pharmacological inhibition of PHGDH have demonstrated …