Cocrystals by design: a rational coformer selection approach for tackling the API problems

M Singh, H Barua, VGSS Jyothi, MR Dhondale… - Pharmaceutics, 2023 - mdpi.com
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …

New Perspectives for Antihypertensive Sartans as Components of Co-crystals and Co-amorphous Solids with Improved Properties and Multipurpose Activity

M Turek, E Różycka-Sokołowska… - Molecular …, 2023 - ACS Publications
Sartans (angiotensin II receptor blockers, ARBs), drugs used in the treatment of
hypertension, play a principal role in addressing the global health challenge of …

[HTML][HTML] Prioritizing computational cocrystal prediction methods for experimental researchers: a review to find efficient, cost-effective, and user-friendly approaches

B Lemli, S Pál, A Széchenyi - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Pharmaceutical cocrystals offer a versatile approach to enhancing the properties of drug
compounds, making them an important tool in drug formulation and development by …

Network pharmacology-based approach to elucidate the pharmacologic mechanisms of natural compounds from Dictyostelium discoideum for Alzheimer's disease …

N Patil, R Dhariwal, A Mohammed, LS Wei, M Jain - Heliyon, 2024 - cell.com
Alzheimer's disease (AD) is increasingly becoming a major public health concern in our
society. While many studies have explored the use of natural polyketides, alkaloids, and …

Multicomponent Amorphous Solid Forms of Telmisartan: Insights into Mechanochemical Activation and Physicochemical Attributes

J Haneef, S Ali - AAPS PharmSciTech, 2024 - Springer
The present work aims to explore the new solid forms of telmisartan (TEL) with alpha-
ketoglutaric acid (KGA) and glutamic acid (GA) as potential coformers using …

Cocrystallization of Gefitinib Potentiate Single-Dose Oral Administration for Lung Tumor Eradication via Unbalancing the DNA Damage/Repair

M Inam, Y Yang, J Hu, J Zheng, W Deng, Y Zhou, J Qi… - Pharmaceutics, 2023 - mdpi.com
Gefitinib (GEF) is a clinical medication for the treatment of lung cancer targeting the
epidermal growth factor receptor (EGFR). However, its efficacy is remarkably limited by low …

Design and Critical Characterization the Pharmaceutical Cocrystal of Azelnidipine With Coformers for Boosting Physicochemical Properties

V Chauhan, R Mardia, M Patel, B Suhagia… - Journal of Pharmaceutical …, 2024 - Springer
Purpose Azelnidipine, a BCS class II antihypertensive medication, is known for its low
solubility and high permeability. In order to enhance its properties, generic GRAS (Generally …

[HTML][HTML] Comparative Proteomic Analysis of Capsule Proteins in Aminoglycoside-Resistant and Sensitive Mycobacterium tuberculosis Clinical Isolates: Unraveling …

D Sharma, S Gautam, N Srivastava… - The International …, 2024 - journals.lww.com
Background: Tuberculosis (TB), a global infectious threat, has seen a concerning rise in
aminoglycoside-resistant Mycobacterium tuberculosis (M. tb) strains. The potential role of …

Assessing the impact of quaternary ammonium compounds with different stoichiometric ratio on atorvastatin calcium solubility

E Azadmanesh, A Jouyban… - Physics and Chemistry …, 2024 - Taylor & Francis
Co-crystallisation of atorvastatin calcium (ATC) at different molar ratio with choline chloride
(CC) and benzalkonium chloride (BAC) was carried out using the solvent evaporation …

Prediction of Chemistry of Cocrystallization and its Realistic Impact on the Enhancement of Solubility and Dissolution of Telmisartan: Molecular mechanics, ab initio …

S Chakraborty, M Dhibar, S Basak… - Current Analytical …, 2024 - benthamdirect.com
Background Cocrystal engineering of Telmisartan (TEL, a poorly soluble antihypertensive
agent) has been undertaken to improve its solubility for the last few years. However, apart …