According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih. gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
As the lipidomics field continues to advance, self-evaluation within the community is critical. Here, we performed an interlaboratory comparison exercise for lipidomics using Standard …
Mass spectrometry is the method of choice for deep and reliable exploration of the (human) proteome. Targeted mass spectrometry reliably detects and quantifies pre-determined sets …
The vast majority of proteomic studies to date have relied on mass spectrometric techniques to identify, and in some cases quantify, peptides that have been generated by proteolysis …
The complexity of proteomic instrumentation for LC-MS/MS introduces many possible sources of variability. Data-dependent sampling of peptides constitutes a stochastic element …
DC Liebler, LJ Zimmerman - Biochemistry, 2013 - ACS Publications
Quantitative measurement of proteins is one of the most fundamental analytical tasks in a biochemistry laboratory, but widely used immunochemical methods often have limited …
High-throughput omics data often contain systematic biases introduced during various steps of sample processing and data generation. As the source of these biases is usually …
CE Parker, CH Borchers - Molecular oncology, 2014 - Elsevier
In its early years, mass spectrometry (MS)-based proteomics focused on the cataloging of proteins found in different species or different tissues. By 2005, proteomics was being used …
Open searching has proven to be an effective strategy for identifying both known and unknown modifications in shotgun proteomics experiments. Rather than being limited to a …