Integrins are key regulators of communication between cells and with their
microenvironment. Eight members of the integrin superfamily recognize the tripeptide motif …

Cancer is one of the major causes of death worldwide. The silent activation of cellular factors
responsible for deviation from normal regulatory pathways leads to the development of …

Integrins comprise a family of 24 heterodimeric transmembrane receptors that mediate cell
attachment to the extracellular matrix and are critical for cell signaling. There are four …

The tumor microenvironment consists of tumor, stromal, and immune cells, as well as
extracellular milieu. Changes in numbers of these cell types and their environments have an …

Leukocyte trafficking is an essential process of immunity, occurring as leukocytes travel
within the bloodstream and as leukocyte migration within tissues. While it is now established …

Alterations in integrin expression and function promote tumour growth, invasion, metastasis
and neoangiogenesis. Head and neck cancers are highly vascular tumours with a tendency …

Cyclic peptides containing the Arg-Gly-Asp (RGD) sequence have been shown to
specifically bind the angiogenesis biomarker α V β 3 integrin. We report the synthesis …

Abstract 'Click'glycosylation of cysteine-containing peptides were carried out in good yield
by Copper (I)-catalyzed Azide–Alkyne Cycloaddition (CuAAC). For that peptides were …

Antagonism of αvβ6 is emerging as a potential treatment of idiopathic pulmonary fibrosis
based on strong target validation. Starting from an αvβ3 antagonist lead and through simple …

The cellular interaction with the extracellular matrix (ECM) modulates many key processes
such as proliferation, migration, differentiation and survival. In addition, cells cultured under …