The vascular endothelium is constantly exposed to mechanical forces, including fluid shear
stress exerted by the flowing blood. Endothelial cells can sense different flow patterns and …

Contact guidance is a powerful topographical cue that induces persistent directional cell
migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix …

The importance of studying cancer cell invasion is highlighted by the fact that 90% of all
cancer-related mortalities are due to metastatic disease. Melanoma metastasis is driven …

The role of mechanical signals in the proper functioning of organisms is increasingly
recognised, and every cell senses physical forces and responds to them. These forces are …

The actin cytoskeleton mediates mechanical coupling between cells and their tissue
microenvironments. The architecture and composition of actin networks are modulated by …

The actin cytoskeleton orchestrates cell mechanics and facilitates the physical integration of
cells into tissues, while tissue‐scale forces and extracellular rigidity in turn govern cell …

All primary chemical interactions weaken under mechanical stress, which imposes
fundamental mechanical limits on the materials constructed from them. Biological materials …

Vinculin, a mechanotransducer associated with both adherens junctions (AJs) and focal
adhesions (FAs), plays a central role in force transmission through cell-cell and cell …

For accurate mitosis, all chromosomes must achieve''bi-orientation', with replicated sister
chromatids coupled via kinetochores to the plus ends of opposing microtubules. However …

Contact guidance is a powerful topographical cue that induces persistent directional cell
migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix …