Malaria remains a major vector borne disease claiming millions of lives worldwide due to
infections caused by Plasmodium sp. Discovery and development of antimalarial drugs have …

In vitro evolution of drug resistance is a powerful approach for identifying antimalarial
targets, however, key obstacles to eliciting resistance are the parasite inoculum size and …

Surveillance of drug resistance and the discovery of novel targets—key objectives in the
fight against malaria—rely on identifying resistance-conferring mutations in Plasmodium …

Introduction Malaria remains a devastating infectious disease with hundreds of thousands of
casualties each year. Antimalarial drug resistance has been a threat to malaria control and …

In the absence of a highly efficacious vaccine, chemotherapy remains the cornerstone to
control malaria morbidity and mortality. The threat of the emergence of parasites resistant to …

Malaria continues to pose a significant burden on populations in endemic areas and
requires innovative treatment options. Here, we report the synthesis and preclinical …

The seeds of Khaya anthotheca,(Welv.) yielded two undescribed limonoids, 1α, 7α-
diacetoxyhavanensin-16-one (1) and 3α, 7α-diacetoxyhavanensin-16-one (2), as well as …

In vitro evolution of drug resistance is a powerful approach for identifying antimalarial
targets, 28 however key obstacles to eliciting resistance are the parasite inoculum size and …