Protein structures are valuable tools to understand protein function. Nonetheless, proteins
are often considered as rigid macromolecules while their structures exhibit specific flexibility …

Chloroplast mRNA populations are characterized by overlapping transcripts derived by
processing from polycistronic precursors. The mechanisms and functional significance of …

Z-nucleic acid structures play vital roles in cellular processes and have implications in innate
immunity due to their recognition by Zα domains containing proteins (Z-DNA/Z-RNA binding …

Background The hierarchical and partially redundant nature of protein structures justifies the
definition of frequently occurring conformations of short fragments as' states'. Collections of …

In this work, we describe the results of a comprehensive structural bioinformatics analysis of
the spliceosomal proteome. We used fold recognition analysis to complement prior data on …

Auditory detection is essential for survival and reproduction of vertebrates, yet the genetic
changes underlying the evolution and diversity of hearing are poorly documented. Recent …

One of the major research directions in bioinformatics is that of assigning superfamily
classification to a given set of proteins. The classification reflects the structural, evolutionary …

Background Protein structure data in Protein Data Bank (PDB) are widely used in studies of
protein function and evolution and in protein structure prediction. However, there are two …

Protein structures are classically described in terms of secondary structures, ie, two regular
states, the alpha-helices and the beta-strands and one default state, the coil. Even if the …

Pathogenic Leptospira is the etiological agent of leptospirosis, a life-threatening disease that
affects populations worldwide. Currently available vaccines have limited effectiveness and …