Single particle tracking: from theory to biophysical applications

H Shen, LJ Tauzin, R Baiyasi, W Wang… - Chemical …, 2017 - ACS Publications
After three decades of developments, single particle tracking (SPT) has become a powerful
tool to interrogate dynamics in a range of materials including live cells and novel catalytic …

A review of progress in single particle tracking: from methods to biophysical insights

C Manzo, MF Garcia-Parajo - Reports on progress in physics, 2015 - iopscience.iop.org
Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Brownian yet non-Gaussian diffusion: from superstatistics to subordination of diffusing diffusivities

AV Chechkin, F Seno, R Metzler, IM Sokolov - Physical Review X, 2017 - APS
A growing number of biological, soft, and active matter systems are observed to exhibit
normal diffusive dynamics with a linear growth of the mean-squared displacement, yet with a …

[HTML][HTML] Anomalous diffusion models and their properties: non-stationarity, non-ergodicity, and ageing at the centenary of single particle tracking

R Metzler, JH Jeon, AG Cherstvy… - Physical Chemistry …, 2014 - pubs.rsc.org
Modern microscopic techniques following the stochastic motion of labelled tracer particles
have uncovered significant deviations from the laws of Brownian motion in a variety of …

Protein crowding in lipid bilayers gives rise to non-Gaussian anomalous lateral diffusion of phospholipids and proteins

JH Jeon, M Javanainen, H Martinez-Seara, R Metzler… - Physical Review X, 2016 - APS
Biomembranes are exceptionally crowded with proteins with typical protein-to-lipid ratios
being around 1∶ 50− 1∶ 100. Protein crowding has a decisive role in lateral membrane …

[HTML][HTML] Heterogeneous anomalous transport in cellular and molecular biology

TA Waigh, N Korabel - Reports on Progress in Physics, 2023 - iopscience.iop.org
It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …

Universal relation between instantaneous diffusivity and radius of gyration of proteins in aqueous solution

E Yamamoto, T Akimoto, A Mitsutake, R Metzler - Physical review letters, 2021 - APS
Protein conformational fluctuations are highly complex and exhibit long-term correlations.
Here, molecular dynamics simulations of small proteins demonstrate that these …

Elucidating the origin of heterogeneous anomalous diffusion in the cytoplasm of mammalian cells

A Sabri, X Xu, D Krapf, M Weiss - Physical Review Letters, 2020 - APS
Diffusion of tracer particles in the cytoplasm of mammalian cells is often anomalous with a
marked heterogeneity even within individual particle trajectories. Despite considerable …

Emergent hydrodynamics in a strongly interacting dipolar spin ensemble

C Zu, F Machado, B Ye, S Choi, B Kobrin, T Mittiga… - Nature, 2021 - nature.com
Conventional wisdom holds that macroscopic classical phenomena naturally emerge from
microscopic quantum laws,,,,,–. However, despite this mantra, building direct connections …

[HTML][HTML] Cytoplasmic RNA-protein particles exhibit non-Gaussian subdiffusive behavior

TJ Lampo, S Stylianidou, MP Backlund, PA Wiggins… - Biophysical journal, 2017 - cell.com
The cellular cytoplasm is a complex, heterogeneous environment (both spatially and
temporally) that exhibits viscoelastic behavior. To further develop our quantitative insight into …