Hereditary spastic paraplegia (HSP) is a syndrome designation describing inherited
disorders in which lower extremity weakness and spasticity are the predominant symptoms …

The cause of Parkinson's disease (PD) remains unknown in most patients. Since 1997, with
the first genetic mutation known to cause PD described in SNCA gene, many other genes …

Objective To date, 3 rare missense mutations in the SNCA (α‐synuclein) gene and the more
frequent duplications or triplications of the wild‐type gene are known to cause a broad array …

The hereditary spastic paraplegias are a heterogeneous group of degenerative disorders
that are clinically classified as either pure with predominant lower limb spasticity, or complex …

Hereditary spastic paraplegia (SPG) is a clinically and genetically heterogeneous group of
neurodegenerative disorders that are clinically characterised by progressive spasticity and …

Seven autosomal recessive genes associated with juvenile and young‐onset Levodopa‐
responsive parkinsonism have been identified. Mutations in PRKN, DJ‐1, and PINK1 are …

In 1997 a mutation in the a-synuclein (SNCA) gene was associated with familial autosomal
dominant Parkinson's disease (PD). Since then, several loci (PARK1‐15) and genes have …

Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders
characterized by progressive spasticity of the lower limbs due to degeneration of the …

Hereditary spastic paraplegias are a heterogeneous group of neurodegenerative disorders,
clinically classified in pure and complex forms. Genetically, more than 70 different forms of …

Hereditary spastic paraplegias (HSP) are rare neurodegenerative diseases sharing the
degeneration of the corticospinal tracts as the main pathological characteristic. They are …