FEBio FINESSE: An open-source finite element simulation approach to estimate in vivo heart valve strains using shape enforcement

DW Laurence, PM Sabin, AM Sulentic… - Annals of Biomedical …, 2024 - Springer
Purpose Finite element simulations are an enticing tool to evaluate heart valve function;
however, patient-specific simulations derived from 3D echocardiography are hampered by …

[HTML][HTML] Functional differences in human aortic valve interstitial cells from patients with varying calcific aortic valve disease

R Tuscher, A Khang, TM West, C Camillo… - Frontiers in …, 2023 - frontiersin.org
Calcific aortic valve disease (CAVD) is characterized by progressive stiffening of aortic valve
(AV) tissues, inducing stenosis and insufficiency. Bicuspid aortic valve (BAV) is a common …

An Inverse Modeling Approach to Estimate Three-Dimensional Aortic Valve Interstitial Cell Stress Fiber Force Levels

A Khang, K Meyer, MS Sacks - Journal of …, 2023 - asmedigitalcollection.asme.org
Within the aortic valve (AV) leaflet exists a population of interstitial cells (AVICs) that
maintain the constituent tissues by extracellular matrix (ECM) secretion, degradation, and …