Spatiotemporal metabolic liver zonation and consequences on pathophysiology
Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis …
The 2022 report on the human proteome from the HUPO human proteome project
The 2022 Metrics of the Human Proteome from the HUPO Human Proteome Project (HPP)
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …
show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 …
The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity
N Martinez-Sanchez, O Sweeney, D Sidarta-Oliveira… - Neuron, 2022 - cell.com
The sympathetic nervous system maintains metabolic homeostasis by orchestrating the
activity of organs such as the pancreas, liver, and white and brown adipose tissues. From …
activity of organs such as the pancreas, liver, and white and brown adipose tissues. From …
Intraocular liver spheroids for non-invasive high-resolution in vivo monitoring of liver cell function
F Lazzeri-Barcelo, N Oliva-Vilarnau, M Baniol… - Nature …, 2024 - nature.com
Longitudinal monitoring of liver function in vivo is hindered by the lack of high-resolution non-
invasive imaging techniques. Using the anterior chamber of the mouse eye as a …
invasive imaging techniques. Using the anterior chamber of the mouse eye as a …
Sympathetic circuits regulating hepatic glucose metabolism: where we stand
A Zsombok, LD Desmoulins… - Physiological …, 2024 - journals.physiology.org
The prevalence of metabolic disorders, including type 2 diabetes mellitus, continues to
increase worldwide. Although newer and more advanced therapies are available, current …
increase worldwide. Although newer and more advanced therapies are available, current …
Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis
H Jun, S Liu, AJ Knights, K Zhu, Y Ma, J Gong… - PLoS …, 2024 - journals.plos.org
Metabolic dysfunction-associated steatohepatitis (MASH) is the progressive form of liver
steatosis, the most common liver disease, and substantially increases the mortality rate …
steatosis, the most common liver disease, and substantially increases the mortality rate …
[HTML][HTML] Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs
Y Nakanishi, M Izumi, H Matsushita, Y Koyama, D Diez… - Neuron, 2024 - cell.com
Regulated neural-metabolic-inflammatory responses are essential for maintaining
physiological homeostasis. However, the molecular machinery that coordinates neural …
physiological homeostasis. However, the molecular machinery that coordinates neural …
A critical update on the l eptin‐melanocortin system
The discovery of leptin in 1994 was an “eureka moment” in the field of neurometabolism that
provided new opportunities to better understand the central control of energy balance and …
provided new opportunities to better understand the central control of energy balance and …
The development of hepatic steatosis depends on the presence of liver-innervating parasympathetic cholinergic neurons in mice fed a high-fat diet
J Hwang, J Okada, L Liu, JE Pessin, GJ Schwartz… - PLoS …, 2024 - journals.plos.org
Hepatic lipid metabolism is regulated by the autonomic nervous system of the liver, with the
sympathetic innervation being extensively studied, while the parasympathetic efferent …
sympathetic innervation being extensively studied, while the parasympathetic efferent …
One nervous system: critical links between central and peripheral nervous system health and implications for obesity and diabetes
KL Townsend - Diabetes, 2024 - diabetesjournals.org
There are key differences between the central nervous system (CNS)(brain and spinal cord)
and peripheral nervous system (PNS), such as glial cell types, whether there is protection by …
and peripheral nervous system (PNS), such as glial cell types, whether there is protection by …