KT Dineley, AA Pandya, JL Yakel - Trends in pharmacological sciences, 2015 - cell.com
The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …
S Lombardo, U Maskos - Neuropharmacology, 2015 - Elsevier
Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …
M Zoli, F Pistillo, C Gotti - Neuropharmacology, 2015 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of pentameric ligand-gated cation channels that are expressed throughout the brain and …
T Fujii, M Mashimo, Y Moriwaki, H Misawa… - Journal of …, 2017 - Elsevier
T and B cells, macrophages and dendritic cells (DCs) all express most of the components necessary for a functional cholinergic system. This includes choline acetyltransferase …
The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel (LGIC) that plays an important role in cellular calcium signaling and contributes to several neurological …
ML Sinkus, S Graw, R Freedman, RG Ross… - …, 2015 - Elsevier
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …
D Xie, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease characterized by progressive cognitive decline and irreversible memory impairment …
D Bertrand, CHL Lee, D Flood, F Marger… - Pharmacological …, 2015 - Elsevier
Progress in the fields of neuroscience and molecular biology has identified the forebrain cholinergic system as being important in many higher order brain functions. Further analysis …
The α7 nicotinic acetylcholine receptor (α7 nAChR) is highly expressed in the brain, where it maintains various neuronal functions including (but not limited to) learning and memory. In …