Expression and function of the cholinergic system in immune cells

T Fujii, M Mashimo, Y Moriwaki, H Misawa… - Frontiers in …, 2017 - frontiersin.org
T and B cells express most cholinergic system components—eg, acetylcholine (ACh),
choline acetyltransferase (ChAT), acetylcholinesterase, and both muscarinic and nicotinic …

Nicotinic ACh receptors as therapeutic targets in CNS disorders

KT Dineley, AA Pandya, JL Yakel - Trends in pharmacological sciences, 2015 - cell.com
The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment

S Lombardo, U Maskos - Neuropharmacology, 2015 - Elsevier
Alzheimer's Disease (AD) is the major form of senile dementia, characterized by neuronal
loss, extracellular deposits, and neurofibrillary tangles. It is accompanied by a loss of …

Diversity of native nicotinic receptor subtypes in mammalian brain

M Zoli, F Pistillo, C Gotti - Neuropharmacology, 2015 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of
pentameric ligand-gated cation channels that are expressed throughout the brain and …

[HTML][HTML] Physiological functions of the cholinergic system in immune cells

T Fujii, M Mashimo, Y Moriwaki, H Misawa… - Journal of …, 2017 - Elsevier
T and B cells, macrophages and dendritic cells (DCs) all express most of the components
necessary for a functional cholinergic system. This includes choline acetyltransferase …

Beyond the channel: metabotropic signaling by nicotinic receptors

N Kabbani, RA Nichols - Trends in pharmacological sciences, 2018 - cell.com
The α7 nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel (LGIC) that
plays an important role in cellular calcium signaling and contributes to several neurological …

The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function

ML Sinkus, S Graw, R Freedman, RG Ross… - …, 2015 - Elsevier
The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is ubiquitously
expressed in both the central nervous system and in the periphery. CHRNA7 is genetically …

The cellular model for Alzheimer's disease research: PC12 cells

D Xie, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …

Therapeutic potential of α7 nicotinic acetylcholine receptors

D Bertrand, CHL Lee, D Flood, F Marger… - Pharmacological …, 2015 - Elsevier
Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Heteromeric α7β2 nicotinic acetylcholine receptors in the brain

J Wu, Q Liu, P Tang, JD Mikkelsen, J Shen… - Trends in …, 2016 - cell.com
The α7 nicotinic acetylcholine receptor (α7 nAChR) is highly expressed in the brain, where it
maintains various neuronal functions including (but not limited to) learning and memory. In …