The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

Sudden cardiac death (SCD) is frequently the initial manifestation of a cardiac arrhythmia,
resulting in about 350 000 deaths annually in the United States. 1 Devices such as the …

The electrical signals triggering the heart's contraction are governed by non-linear
processes that can produce complex irregular activity, especially during or preceding the …

Individuals with chronic heart failure (CHF) have an increased risk of ventricular arrhythmias,
which has been linked to pathological cellular remodeling and may also be mediated by …

Atrial fibrillation (AF) is a major cause of heart failure and stroke. The early maintenance of
sinus rhythm has been shown to reduce major cardiovascular endpoints, yet is difficult to …

Even after over a century of active research, the heart continues to reveal new complexities
in behavior and remains difficult to understand fully. Multi-scale dynamics ranging from …

Cardiac alternans, a beat-to-beat alternation in action potential duration (APD), can lead to
fatal arrhythmias. During periodic pacing, changes in diastolic interval (DI) depend on …

Life‐threatening ventricular arrhythmias and sudden cardiac death are often preceded by
cardiac alternans, a beat‐to‐beat oscillation in the T‐wave morphology or duration …

Modelling of cardiac electrical behaviour has led to important mechanistic insights, but
important challenges, including uncertainty in model formulations and parameter values …

The beat-to-beat alternation in action potential durations (APDs) in the heart, called APD
alternans, has been linked to the development of serious cardiac rhythm disorders, including …