Drug delivery strategies and nanozyme technologies to overcome limitations for targeting oxidative stress in osteoarthritis

JL Aldrich, A Panicker, R Ovalle Jr, B Sharma - Pharmaceuticals, 2023 - mdpi.com
Oxidative stress is an important, but elusive, therapeutic target for osteoarthritis (OA).
Antioxidant strategies that target oxidative stress through the elimination of reactive oxygen …

Advances in porphyrins and chlorins associated with polysaccharides and polysaccharides-based materials for biomedical and pharmaceutical applications

RFN Quadrado, S Silvestri, JF de Souza… - Carbohydrate …, 2024 - Elsevier
Over the last decade, the convergence of advanced materials and innovative applications
has fostered notable scientific progress within the biomedical and pharmaceutical fields …

Identification of compounds that cause axonal dieback without cytotoxicity in dorsal root ganglia explants and intervertebral disc cells with potential to treat pain via …

FS Lee, UN Nguyen, EJ Munns, RA Wachs - Plos one, 2024 - journals.plos.org
Low back pain, knee osteoarthritis, and cancer patients suffer from chronic pain. Aberrant
nerve growth into intervertebral disc, knee, and tumors, are common pathologies that lead to …

Screening for axonal retraction and cytotoxicity using dorsal root ganglia explants to treat pain caused by aberrant nerve sprouting

F San Lee, UN Nguyen, EJ Munns, RA Wachs - 2023 - researchsquare.com
Low back pain, knee osteoarthritis and cancer patients suffer from chronic pain. Aberrant
nerve growth into intervertebral disc, knee, and tumors, are common pathologies that lead to …

Engineering of Microparticle Encapsulated Antioxidant to Mitigate Oxidative Stress in vitro and in vivo

K Ney - 2023 - digitalcommons.unl.edu
Chronic low back pain (cLBP) is one of the leading causes of years lived with disability in the
United States. Current treatments for cLBP have variable results across the patient …

Investigation of Repurposing Pyridoxine and Vincristine as Novel Axonal Dieback Compounds to Treat Disc-Associated Low Back Pain

F San Lee - 2023 - search.proquest.com
Low back pain is a major global cause of disability. Aberrant nerve growth in degenerated
discs is a common pathological feature and source of chronic disc-associated low back pain …