Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus
(EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …

Viruses frequently carry out replication in specialized compartments within cells. The effect
of these structures on virus replication is poorly understood. Recent research supports …

Background Ebolavirus species Zaire (ZEBOV) causes highly lethal hemorrhagic fever,
resulting in the death of 90% of patients within days. Most information on immune responses …

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory
infections that can be life-threatening. To establish an infection and spread, MERS-CoV, like …

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …

During viral RNA synthesis, Ebola virus (EBOV) nucleoprotein (NP) alternates between an
RNA-template-bound form and a template-free form to provide the viral polymerase access …

ABSTRACT The Ebola virus (EBOV) VP35 protein antagonizes the early antiviral alpha/beta
interferon (IFN-α/β) response. We previously demonstrated that VP35 inhibits the virus …

Abstract Ebolaviruses and Marburgviruses (family Filoviridae) are among the most virulent
pathogens for humans and great apes causing severe haemorrhagic fever and death within …