Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

With advances in neonatal care, preterm neonates are surviving with an evolving
constellation of motor and cognitive disabilities that appear to be related to widespread …

Epilepsy and intellectual disability are associated with rare variants in the GluN2A and
GluN2B (encoded by GRIN2A and GRIN2B) subunits of the N-methyl-D-aspartate receptor …

Schizophrenia is associated with alterations in sensory, motor, and cognitive functions that
emerge before psychosis onset; identifying pathogenic processes that can account for this …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

N‐methyl‐D‐aspartate receptors (NMDARs) mediate slow excitatory postsynaptic
transmission in the central nervous system, thereby exerting a critical role in neuronal …

Alterations in synaptic signaling and plasticity occur during the refinement of neural circuits
over the course of development and the adult processes of learning and memory. Synaptic …

Mutations of MECP2 cause Rett syndrome (RTT), a neurodevelopmental disorder leading to
loss of motor and cognitive functions, impaired social interactions, and seizure at young …

Selective elimination of unwanted synapses is vital for the precise formation of neuronal
circuits during development, but the underlying mechanisms remain unclear. Using inositol …

Background The brain undergoes dynamic and requisite changes into the early 20s that are
associated with improved cognitive efficiency, particularly in prefrontal regions that are still …