Adenovirus VA RNA: an essential pro-viral non-coding RNA

VK Vachon, GL Conn - Virus research, 2016 - Elsevier
Abstract Adenovirus (AdV)'virus-associated'RNAs (VA RNAs) are exceptionally abundant
(up to 10 8 copies/cell), heterogeneous, non-coding RNA transcripts (∼ 150–200 …

Circulating miRNAs as potential biomarkers in myasthenia gravis: tools for personalized medicine

L Sabre, T Punga, AR Punga - Frontiers in immunology, 2020 - frontiersin.org
Myasthenia gravis (MG) is an autoimmune disease caused by antibodies which attack
receptors at the neuromuscular junction. One of the main difficulties in predicting the clinical …

Circulating mi RNA s in myasthenia gravis: miR‐150‐5p as a new potential biomarker

T Punga, R Le Panse, M Andersson… - Annals of clinical …, 2014 - Wiley Online Library
Objective Myasthenia gravis (MG) is a chronic autoimmune disorder where autoantibodies
target the nicotinic acetylcholine receptors (AChR+) in about 85% of cases, in which the …

Circulating microRNAs as potential biomarkers in myasthenia gravis patients

AR Punga, T Punga - Annals of the New York Academy of …, 2018 - Wiley Online Library
MicroRNAs (miRNAs) are small noncoding RNA molecules that bind to specific mRNA
targets and regulate a wide range of important biological processes within cells. Circulating …

Synthesis, structure, and function of human adenovirus small non-coding RNAs

T Punga, M Darweesh, G Akusjärvi - Viruses, 2020 - mdpi.com
Human adenoviruses (HAdVs) are common pathogens causing a variety of respiratory,
ocular and gastrointestinal diseases. To accomplish their efficient replication, HAdVs take an …

Adenovirus VA RNAI blocks ASC oligomerization and inhibits NLRP3 inflammasome activation

M Darweesh, W Kamel, MA Gavrilin… - Frontiers in …, 2019 - frontiersin.org
Virus infected immune cells can rapidly respond to the invader by activating the
inflammasome and as a consequence release proinflammatory cytokines and eventually die …

Adenoviruses

O Ruuskanen, JP Metcalf, O Meurman… - Clinical …, 2009 - Wiley Online Library
The human adenoviruses comprise 51 distinct serotypes that are grouped into six
subgroups (A to F) based on various immunologic, biological, and biochemical …

MicroRNAs as important players in host–adenovirus interactions

D Piedade, JM Azevedo-Pereira - Frontiers in Microbiology, 2017 - frontiersin.org
MicroRNAs (miRNAs) are powerful regulators of gene expression and fine-tuning genes in
all tissues. Cellular miRNAs can control 100s of biologic processes (eg, morphogenesis of …

Small RNA sequence analysis of adenovirus VA RNA-derived miRNAs reveals an unexpected serotype-specific difference in structure and abundance

W Kamel, B Segerman, T Punga, G Akusjärvi - PLoS One, 2014 - journals.plos.org
Human adenoviruses (HAds) encode for one or two highly abundant virus-associated RNAs,
designated VA RNAI and VA RNAII, which fold into stable hairpin structures resembling …

Adenovirus in the omics era–A multipronged strategy

H Zhao, T Punga, U Pettersson - FEBS letters, 2020 - Wiley Online Library
Human adenoviruses (HAdVs) are common pathogens associated with a wide variety of
respiratory, ocular, and gastrointestinal diseases. To achieve its effective lytic mode of …