Exercise elicits coordinated multi-organ responses including skeletal muscle, vasculature,
heart, and lung. In the short term, the output of the heart increases to meet the demand of …

Ischemic heart disease is the leading cause of death worldwide. Myocardial infarction
results in an irreversible loss of cardiomyocytes with subsequent adverse remodeling and …

Abstract Mitochondrial calcium (mCa2+) has a central role in both metabolic regulation and
cell death signalling, however its role in homeostatic function and disease is controversial …

The Cre–loxP recombination system is the most widely used technology for in vivo tracing of
stem or progenitor cell lineages. The precision of this genetic system largely depends on the …

Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating
research to improve diagnostics, and to discover and test novel preventive and curative …

Aims Obesity and type 2 diabetes (T2D) trigger a harmful stress-induced cardiac remodeling
process known as cardiomyopathy. These diseases represent a serious and widespread …

The brainstem locus coeruleus (LC) supplies norepinephrine to the forebrain and
degenerates in Alzheimer's disease (AD). Loss of LC neurons is correlated with increased …

Abstract MITOL/MARCH5 is an E3 ubiquitin ligase that plays a crucial role in the control of
mitochondrial quality and function. However, the significance of MITOL in cardiomyocytes …

Alzheimer disease (AD) is a medically and financially overwhelming condition, and
incidence rates are expected to triple by 2050. Despite decades of research in animal …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …