Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

Histopathological grading of epithelial dysplasia remains the principal laboratory method for
assessing the risk of malignant transformation in oral potentially malignant disorders …

Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

The tumor ecosystem of papillary thyroid carcinoma (PTC) is poorly characterized. Using
single-cell RNA sequencing, we profile transcriptomes of 158,577 cells from 11 patients' …

Abstract The European Collaborative on Personalized Early Detection and Prevention of
Breast Cancer (ENVISION) brings together several international research consortia working …

Prostate cancer is characterized by a high degree of heterogeneity, which poses a major
challenge to precision therapy and drug development. In this review, we discuss how …

Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and,
despite treatment, a small fraction (5–10%) of DCIS patients develop subsequent invasive …

Cancers develop due to the accumulation of genetic and epigenetic alterations. Genetic
alterations are induced by aging, mutagenic chemicals, ultraviolet light, and other factors; …

Field cancerization and metastasis are the leading causes for cancer recurrence and
mortality in cancer patients. The formation of primary, secondary tumors or metastasis is …

Clinical implementation of tumor organoids for personalized medicine requires that pure
tumor organoids can be reliably established. Here, we present our experience with organoid …