New and emerging oral therapies for psoriasis

O Yilmaz, JP Pinto, T Torres - Drugs in Context, 2024 - pmc.ncbi.nlm.nih.gov
Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the global population.
Traditional systemic treatments, such as methotrexate, cyclosporine, acitretin and fumaric …

Inhibition of the JAK-STAT Pathway in the Treatment of Psoriasis: A Review of the Literature

AR Furtunescu, SR Georgescu, M Tampa… - International Journal of …, 2024 - mdpi.com
Psoriasis is a highly prevalent dermatological disease associated with an increased
systemic inflammatory response. In addition, joint involvement is also present in around 20 …

Design, Synthesis, and Biological Evaluation of New Selective PDE4 Inhibitors for Topical Treatment of Psoriasis

D He, G Li, JQ Wu, Y Geng, X Qian, Y Liu… - Journal of Medicinal …, 2024 - ACS Publications
Psoriasis is a complex and chronic inflammatory disease. Current drugs help control the
symptoms of psoriasis but make no cure, urging discovery of novel drugs. We report in this …

[HTML][HTML] Cannabidiol Alleviates Imiquimod-Induced Psoriasis by Inhibiting JAK2–STAT3 in a Mouse Model

MS Kim, JH Lee, SW Kim, CH Bang - Biomedicines, 2024 - mdpi.com
Cannabidiol (CBD), a non-psychoactive compound from Cannabis sativa, has shown
efficacy in treating psoriasis, a chronic inflammatory skin disease affecting 1–3% of the …

Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments

F Zhao, J Zhao, K Wei, P Jiang, Y Shi… - ImmunoTargets and …, 2024 - Taylor & Francis
Psoriasis is a chronic inflammatory skin disease characterized by the excessive proliferation
of keratinocytes and heightened immune activation. Targeting pathogenic genes through …

Novel pharmacotherapies and breakthroughs in psoriasis treatment: 2024 and beyond

A Portarapillo, L Potestio, N Tommasino… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction The use of the current available therapies for psoriasis management may
sometimes be limited by reduced patients' compliance, safety issues for patients' …

Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions

A Radu, DM Tit, LM Endres, AF Radu, CM Vesa… - …, 2024 - Springer
Psoriasis represents a chronic autoimmune skin condition defined by various clinical forms,
including inverse, erythrodermic, pustular, guttate, plaque types. While current therapies …

[HTML][HTML] Formulation and Evaluation of Different Nanogels of Tapinarof for Treatment of Psoriasis

B Balogh, Á Pető, Á Haimhoffer, D Sinka, D Kósa… - Gels, 2024 - mdpi.com
Psoriasis is an immune-mediated skin condition. There are many therapeutic options for its
treatment; however, none of them is completely effective. Tapinarof is a promising new …

[HTML][HTML] Th Pathways in Immune-Mediated Skin Disorders: A Guide for Strategic Treatment Decisions

R Speeckaert, A Belpaire, J Lambert… - Immune …, 2024 - pmc.ncbi.nlm.nih.gov
In recent years, there have been significant breakthroughs in the identification of
immunological components of skin diseases and in the development of immunomodulatory …

Association of psoriasis disease with physical activity and exercise: systematic review and meta-analysis

H Zhu, Q Sun, H Choi, Y Li, W Zhang - Advances in Dermatology and …, 2024 - termedia.pl
Aim: Meta-analysis study to investigate the physical activity in psoriasis patients. Methods:
We designed this study according to the Systematic Reviews and Meta-Analyses (PRISMA) …