Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

The essential role of ORAI1 channels in receptor-evoked Ca2+ signaling is well understood,
yet little is known about the physiological activation of the ORAI channel trio natively …

Endothelial cells (ECs) are highly specialized across vascular beds. However, given their
interspersed anatomic distribution, comprehensive characterization of the molecular basis …

While extensive research has demonstrated an interdependent role of osteogenesis and
angiogenesis in bone tissue engineering, little is known about how functional blood vessel …

Epigenetic mechanisms, especially DNA methylation and histone modifications, are
dynamic processes that regulate the gene expression transcriptional program in normal and …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Store-operated Ca2+ entry (SOCE) is activated in response to the inositol-1, 4, 5-
trisphosphate (InsP3)-dependent depletion of the endoplasmic reticulum (ER) Ca2+ store …

Anthocyanins are a subgroup of flavonoid polyphenols previously investigated for improving
cardiovascular health and preventing the development of endothelial dysfunction. However …

Abstract Intracellular calcium (Ca 2+) is an essential second messenger in eukaryotic cells
regulating numerous cellular functions such as contraction, secretion, immunity, growth, and …