The foundations of immune checkpoint blockade and the ipilimumab approval decennial

AJ Korman, SC Garrett-Thomson… - Nature Reviews Drug …, 2022 - nature.com
Cancer immunity, and the potential for cancer immunotherapy, have been topics of scientific
discussion and experimentation for over a hundred years. Several successful cancer …

Improving CAR-T immunotherapy: overcoming the challenges of T cell exhaustion

D Gumber, LD Wang - EBioMedicine, 2022 - thelancet.com
Chimeric antigen receptor (CAR) T cell therapy has emerged as a cancer treatment with
enormous potential, demonstrating impressive antitumor activity in the treatment of …

Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines

P Glynne, N Tahmasebi, V Gant… - Journal of Investigative …, 2022 - journals.sagepub.com
Long COVID is characterized by the emergence of multiple debilitating symptoms following
SARS-CoV-2 infection. Its etiology is unclear and it often follows a mild acute illness …

Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells

S Nkongolo, D Mahamed, A Kuipery… - The Journal of …, 2023 - Am Soc Clin Investig
Accumulation of activated immune cells results in nonspecific hepatocyte killing in chronic
hepatitis B (CHB), leading to fibrosis and cirrhosis. This study aims to understand the …

[HTML][HTML] Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection

JK Files, S Boppana, MD Perez… - The Journal of …, 2021 - Am Soc Clin Investig
Ongoing observational clinical research has prioritized understanding the human immune
response to SARS-CoV-2 during the coronavirus disease 2019 (COVID-19) pandemic …

The role of PD-1 signaling in health and immune-related diseases

RY Chen, Y Zhu, YY Shen, QY Xu, HY Tang… - Frontiers in …, 2023 - frontiersin.org
Programmed cell death 1 receptor (PD-1) and its ligands constitute an inhibitory pathway to
mediate the mechanism of immune tolerance and provide immune homeostasis …

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

J Westmeier, K Paniskaki, Z Karaköse, T Werner… - MBio, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

Soluble PD-1: predictive, prognostic, and therapeutic value for cancer immunotherapy

M Khan, Z Zhao, S Arooj, Y Fu, G Liao - Frontiers in immunology, 2020 - frontiersin.org
Programmed death protein 1 (PD-1) interaction with PD-L1 deliver immunosuppressive
environment for tumor growth, and its blockade with directed monoclonal antibodies (anti …

Persistent cellular immunity to SARS-CoV-2 infection

G Breton, P Mendoza, T Hägglöf, TY Oliveira… - Journal of Experimental …, 2021 - rupress.org
SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of
individuals around the globe. To gain further understanding of the immune response in …

Lymphopenia caused by virus infections and the mechanisms beyond

Z Guo, Z Zhang, M Prajapati, Y Li - Viruses, 2021 - mdpi.com
Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …