Membrane association is a hallmark of the genome replication of positive-strand RNA
viruses [(+) RNA viruses]. All well-studied (+) RNA viruses remodel host membranes and …

The TBC (T re-2/B ub2/C dc16) domain was originally identified as a conserved domain
among the tre-2 oncogene product and the yeast cell cycle regulators Bub2 and Cdc16, and …

Supported lipid bilayers (SLBs) mimic biological membranes and are a versatile platform for
a wide range of biophysical research fields including lipid–protein interactions, protein …

Abstract The Tre2–Bub2–Cdc16 (TBC) domain-containing RAB-specific GTPase-activating
proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC …

Highlights•+ RNA viruses build membranous VRCs.•+ RNA viruses rewire cellular lipid
metabolism to build VRCs.•VRC structure and formation mechanisms differ between …

Hepatitis C virus (HCV) is a single-stranded RNA virus that replicates on endoplasmic
reticulum-derived membranes. HCV particle assembly is dependent on the association of …

Viruses are obligate intracellular pathogens that are dependent on cellular machineries for
their replication. Recent technological breakthroughs have facilitated reliable identification …

HCV (hepatitis C virus) infects nearly 3% of the population worldwide and has emerged as a
major causative agent of liver disease, resulting in acute and chronic infections that can lead …

Replication of hepatitis C virus (HCV) RNA occurs on intracellular membranes, and the
replication complex (RC) contains viral RNA, nonstructural proteins, and cellular cofactors …

Like other viruses, productive hepatitis C virus (HCV) infection depends on certain critical
host factors. We have recently shown that an interaction between HCV nonstructural protein …