Neural crest cells (NCCs) are a dynamic, multipotent, vertebrate-specific population of
embryonic stem cells. These ectodermally-derived cells contribute to diverse tissue types in …

Mitochondrial activity differs markedly between organs, but it is not known how and when
this arises. Here we show that cell lineage-specific expression profiles involving essential …

Cardiovascular disease (CVD) remains a global economic burden even in the 21st century
with 85% of deaths resulting from heart attacks. Despite efforts in reducing the risk factors …

Nager syndrome (NS) is a rare acrofacial dysostosis caused by heterozygous loss-of-
function variants in the splicing factor 3B subunit 4 (SF3B4). The main clinical features of …

Neural crest-like stem cells resembling embryonic neural crest cells (NCs) can be derived
from adult human tissues such as the epidermis. However, these cells lose their …

Although dose-response analyses are a fundamental tool in developmental toxicology, few
studies have examined the impacts of toxicant dose on the non-genetic paternal inheritance …

Neurodevelopmental proteasomopathies constitute a recently defined class of rare
Mendelian disorders, arising from genomic alterations in proteasome-related genes. These …

Heart failure (HF) represents the terminal stage of cardiovascular diseases, with limited
therapeutic options currently available. Calotropin (CAL), a cardenolide isolated from …

Abstract Tissue Transglutaminases (TGs) are crosslinking enzymes with pleiotropic
functions that have been linked to the development and progression of numerous cancers …

Mitochondria are cytoplasmic organelles having a fundamental role in the regulation of
neural stem cell (NSC) fate during neural development and maintenance. During embryonic …