[HTML][HTML] Natural products in drug discovery: advances and opportunities
AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
Genome mining methods to discover bioactive natural products
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
Valinophos reveals a new route in microbial phosphonate biosynthesis that is broadly conserved in nature
Phosphonate natural products are potent inhibitors of cellular metabolism with an
established record of commercialization in medicine and biotechnology. Although genome …
established record of commercialization in medicine and biotechnology. Although genome …
A phosphonate natural product made by Pantoea ananatis is necessary and sufficient for the hallmark lesions of onion center rot
Pantoea ananatis is the primary cause of onion center rot. Genetic data suggest that a
phosphonic acid natural product is required for pathogenesis; however, the nature of the …
phosphonic acid natural product is required for pathogenesis; however, the nature of the …
Biosynthesis of Argolaphos Illuminates the Unusual Biochemical Origins of Aminomethylphosphonate and Nε-Hydroxyarginine Containing Natural Products
Phosphonate natural products have a history of successful application in medicine and
biotechnology due to their ability to inhibit essential cellular pathways. This has inspired …
biotechnology due to their ability to inhibit essential cellular pathways. This has inspired …
Exploitation of microbial activities at low pH to enhance planetary health
M Atasoy, A Álvarez Ordóñez, A Cenian… - FEMS Microbiology …, 2024 - academic.oup.com
Awareness is growing that human health cannot be considered in isolation but is
inextricably woven with the health of the environment in which we live. It is, however, under …
inextricably woven with the health of the environment in which we live. It is, however, under …
Convergent and divergent biosynthetic strategies towards phosphonic acid natural products
The phosphonate class of natural products have received significant interests in the post-
genomic era due to the relative ease with which their biosynthetic genes may be identified …
genomic era due to the relative ease with which their biosynthetic genes may be identified …
Phosphonoalamides reveal the biosynthetic origin of phosphonoalanine natural products and a convergent pathway for their diversification
Phosphonate natural products, with their potent inhibitory activity, have found widespread
use across multiple industries. Their success has inspired development of genome mining …
use across multiple industries. Their success has inspired development of genome mining …
Biosynthesis of the Fungal Organophosphonate Fosfonochlorin Involves an Iron (II) and 2‐(Oxo) glutarate Dependent Oxacyclase
SR Gama, T Stankovic, K Hupp, A Al Hejami… - …, 2022 - Wiley Online Library
The fungal metabolite Fosfonochlorin features a chloroacetyl moiety that is unusual within
known phosphonate natural product biochemistry. Putative biosynthetic genes encoding …
known phosphonate natural product biochemistry. Putative biosynthetic genes encoding …