In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …

Endothelial cells that line the inner walls of blood vessels are in direct contact with blood
and display remarkable heterogeneity in their response to exogenous stimuli. These ECs …

Endothelial cells and mesenchymal cells are two different cell types with distinct
morphologies, phenotypes, functions, and gene profiles. Accumulating evidence, notably …

1164 Circulation Research April 12, 2019 blocked the EndMT and fibrotic markers and
reduced migration of TGFβ-treated valve endothelial cells. CD45 is not normally expressed …

Functional or secondary mitral regurgitation (MR) is associated with increased
cardiovascular morbidity and mortality. Mechanistically, secondary MR is attributable to an …

During the last decade, the endothelial-to-mesenchymal transition (EndMT) process has
attracted considerable attention due to associations with the onset of certain diseases, such …

Objectives: This study hypothesized that compensatory mitral leaflet area (MLA) adaptation
occurs in patients with persistent atrial fibrillation (AF) without left ventricular (LV) dysfunction …

In a myocardial infarction, blood supply to the left ventricle is abrogated due to blockage of
one of the coronary arteries, leading to ischemia, which further triggers the generation of …