Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by
chronic and heterogeneous manifestations, induced by interacting environmental, genomic …

Compared with normal cells, tumor cells have undergone an array of genetic and epigenetic
alterations. Often, these changes underlie cancer development, progression, and drug …

High-throughput and high-content databases are increasingly important resources in
molecular medicine, systems biology, and pharmacology. However, the information usually …

Background: The latest research identified cuproptosis as an entirely new mechanism of cell
death. However, as a key regulator in copper-induced cell death, the prognostic and …

P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …

Background: Hepatocellular carcinoma (HCC) is characterized by a poor prognosis and
accounts for the fourth common cause of cancer-related deaths. Recently, pyroptosis has …

Background To leverage the potential of multi-omics studies, exploratory data analysis
methods that provide systematic integration and comparison of multiple layers of omics …

Uterine corpus endometrial carcinoma (UCEC) is a malignant disease globally, and there is
no unified prognostic signature at present. In our study, two clusters were identified. Cluster …

DNA-damaging agents (DDAs) constitute the backbone of treatment for most human tumors.
Here we used the National Cancer Institute Antitumor Cell Line Panel (the NCI-60) to identify …

Alternative splicing is a vast source of biological regulation and diversity that is misregulated
in cancer and other diseases. To investigate global control of alternative splicing in human …