This review addresses the possibilities of using supercritical carbon dioxide (SC-CO2) in the
flavor industry in extraction and fractionation processes and its use as a reaction medium to …

Cancer poses a substantial global health challenge, necessitating the widespread use of
chemotherapy and radiotherapy. Despite these efforts, issues like resistance development …

Glioblastoma (GBM) is the most aggressive primary brain tumor, exhibiting a high rate of
recurrence and poor prognosis. Surgery and chemoradiation with temozolomide (TMZ) …

Perillyl alcohol (POH) is a naturally occurring monoterpenoid related to limonene that is
present in the essential oils of various plants. It has diverse applications and can be found in …

OBJECTIVE Malignancies of the CNS are difficult to treat because the blood-brain barrier
(BBB) prevents most therapeutics from reaching the intracranial lesions at sufficiently high …

Simple Summary Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow,
where cancer cells are unable to complete the maturation process towards white blood cells …

OBJECTIVE Diffuse midline gliomas, including diffuse intrinsic pontine gliomas (DIPGs), are
among the most malignant and devastating childhood brain cancers. Despite aggressive …

OBJECTIVE Immune checkpoint-inhibitory therapeutic antibodies have shown striking
activity against several types of cancers but are less effective against brain-localized …

BACKGROUND Intranasal delivery of NEO100, a pharmaceutical-grade version of the
natural monoterpene perillyl alcohol (POH), is undergoing clinical phase IIa testing as a …

Background Perillyl alcohol (POH) is a aroma monoterpene commonly obtained from
various plants' essential oil. Recently, increasing researches have demonstrated that POH …