Design, classification, and adverse effects of NSAIDs: A review on recent advancements

M Arfeen, A Srivastava, N Srivastava, RA Khan… - Bioorganic & Medicinal …, 2024 - Elsevier
Inflammation is a hallmark of many diseases, including cancer, neurodegenerative diseases
like Alzheimer's, type II diabetes, rheumatoid arthritis, and asthma. Nonsteroidal anti …

Design, synthesis, antibacterial evaluations and in silico studies of novel thiosemicarbazides and 1, 3, 4-thiadiazoles

S Janowska, D Khylyuk, S Andrzejczuk, M Wujec - Molecules, 2022 - mdpi.com
The emergence of drug-resistant bacterial strains continues to be one of the major
challenges of medicine. For this reason, the importance of searching for novel structures of …

[HTML][HTML] The Importance of Substituent Position for Antibacterial Activity in the Group of Thiosemicarbazide Derivatives

S Janowska, J Stefańska, D Khylyuk, M Wujec - Molecules, 2024 - mdpi.com
The search for new antibacterial compounds is still a huge challenge for scientists. Each
new chemotherapy drug is not 100% effective when introduced into treatment. Bacteria …

X-ray Structures and Computational Studies of Two Bioactive 2-(Adamantane-1-carbonyl)-N-substituted Hydrazine-1-carbothioamides

LH Al-Wahaibi, K Alagappan, O Blacque… - Molecules, 2022 - mdpi.com
Two biologically active adamantane-linked hydrazine-1-carbothioamide derivatives, namely
2-(adamantane-1-carbonyl)-N-(tert-butyl) hydrazine-1-carbothioamide) 1 and 2 …

New Thiosemicarbazide Derivatives with Multidirectional Biological Action

P Lasek, U Kosikowska, P Kołodziej… - Molecules, 2024 - mdpi.com
Over the years, several new medicinal substances have been introduced for the treatment of
diseases caused by bacteria and parasites. Unfortunately, due to the production of …

[PDF][PDF] In silico studies and in vitro microsomal metabolism of potent MetAP2 inhibitor and in vivo tumor suppressor for prostate cancer: A thioether-triazole hybrid

G Coşkun, K Birgül, AE Evren… - Acıbadem …, 2023 - dergipark.org.tr
Materials and methods: In the present study, the sulfoxide metabolite was synthesized,
purified and characterized by chromatographic and spectroscopic methods. SGK636, the S …

Synthesis, Characterization, Antimicrobial and In Silico Studies of isatin Schiff base linked 1, 2, 3‐triazole hybrids

V Kumar, A Bhukal, APS Raman… - Chemistry & …, 2024 - Wiley Online Library
A new series of isatin‐Schiff base linked 1, 2, 3‐triazole hybrids has been synthesized using
CuAAC approach from (E)‐3‐(phenylimino)‐1‐(prop‐2‐yn‐1‐yl) indolin‐2‐one derivatives …

New Hybrid Compounds from Imidazole and 1, 2, 3-Triazole: efficient Synthesis of Highly Substituted Imidazoles and Construction of Their Novel Hybrid Compounds …

M Hashemipour, A Keivanloo… - Polycyclic Aromatic …, 2024 - Taylor & Francis
New hybrid compounds were successfully prepared from highly substituted imidazoles and
1, 2, 3-triazoles using copper-catalyzed click reactions. Also, an efficient method described …

Synthesis, spectral characteristics and molecular structure of N-(2, 2, 2-trichloro-1-(hydrazinecarbothioamido) ethyl) carboxamides

VV Pavlova, PV Zadorozhnii, VV Kiselev… - Chemical Data …, 2024 - Elsevier
Thiosemicarbazide derivatives are widely used as substrates for organic synthesis, and as
analytical reagents and have a wide range of biological activities. In this work, we report …

Recent advances in pharmacologically important 1, 2, 4-triazoles as promising antifungal agents against Candida albicans

C Raafat, TFS Ali, GAA Abuo-Rahma - Octahedron Drug Research, 2024 - journals.ekb.eg
Candida infections are quite prevalent and constitute a significant etiological factor in the
development of severe medical diseases attributed to fungal pathogens. This is particularly …