DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Neurodegenerative diseases represent some of the most devastating neurological
disorders, characterized by progressive loss of the structure and function of neurons. Current …

The advent of induced pluripotent stem cell (iPSC)-derived neurons has revolutionized
Parkinson's disease (PD) research, but single-cell transcriptomic analysis suggests …

This article reviews available data regarding the possible association of organophosphorus
(OP) pesticides with neurological disorders such as dementia, attention deficit hyperactivity …

Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the
death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD …

PON1, PON2, and PON3 belong to a family of lactone hydrolyzing enzymes endowed with
various substrate specificities. Among PONs, PON2 shows the highest hydrolytic activity …

The substantial contributions of Dr. Gerald Stern to past and current treatments for
Parkinson's disease patients are reviewed, which form the foundation for an evaluation of …

The DJ-1 protein was originally linked with Parkinson's disease and is now known to have
antioxidant functions. The protein has three redox-sensitive cysteine residues, which are …

Abstract Paraoxonase 2 (PON2) is a ubiquitously expressed intracellular enzyme that is
known to have a protective role from oxidative stress. Clinical studies have also …

Organophosphates (OPs) refers to a diverse group of phosphorus-containing organic
compounds; they are widely used all over the world and have had an important beneficial …