Changes in lean body mass with glucagon‐like peptide‐1‐based therapies and mitigation strategies

IJ Neeland, J Linge… - Diabetes, Obesity and …, 2024 - Wiley Online Library
Weight loss induced by glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and dual
glucagon‐like peptide‐1 receptor (GLP‐1R)/glucose‐dependent insulinotropic polypeptide …

Muscle mass and glucagon-like peptide-1 receptor agonists: adaptive or maladaptive response to weight loss?

J Linge, AL Birkenfeld, IJ Neeland - Circulation, 2024 - ahajournals.org
Recent studies have shown that pharmacologic weight loss with glucagon-like peptide-1
receptor agonists (GLP-1 RAs) and combination therapies is approaching magnitudes …

Safety and efficacy of losmapimod in facioscapulohumeral muscular dystrophy (ReDUX4): a randomised, double-blind, placebo-controlled phase 2b trial

R Tawil, KR Wagner, JI Hamel, DG Leung… - The Lancet …, 2024 - thelancet.com
Background Facioscapulohumeral muscular dystrophy is a hereditary progressive myopathy
caused by aberrant expression of the transcription factor DUX4 in skeletal muscle. No …

Five‐year follow‐up study on quantitative muscle magnetic resonance imaging in facioscapulohumeral muscular dystrophy: The link to clinical outcome

SCC Vincenten, K Mul, D van As… - Journal of Cachexia …, 2023 - Wiley Online Library
Background It is unclear how changes in quantitative muscle magnetic resonance imaging
(MRI) relate to changes in clinical outcome in facioscapulohumeral muscular dystrophy …

The FSHD jigsaw: are we placing the tiles in the right position?

V Salsi, GNA Vattemi, RG Tupler - Current Opinion in Neurology, 2023 - journals.lww.com
The FSHD jigsaw: are we placing the tiles in the right posit... : Current Opinion in Neurology
The FSHD jigsaw: are we placing the tiles in the right position? : Current Opinion in Neurology …

Lower limb muscle MRI fat fraction is a responsive outcome measure in CMT X1, 1B and 2A

CM Doherty, JM Morrow, R Zuccarino… - Annals of clinical …, 2024 - Wiley Online Library
Objective With potential therapies for many forms of Charcot‐Marie‐Tooth disease (CMT),
responsive outcome measures are urgently needed for clinical trials. Quantitative lower limb …

AI driven analysis of MRI to measure health and disease progression in FSHD

L Riem, O DuCharme, M Cousins, X Feng, A Kenney… - Scientific reports, 2024 - nature.com
Facioscapulohumeral muscular dystrophy (FSHD) affects roughly 1 in 7500 individuals.
While at the population level there is a general pattern of affected muscles, there is …

Influence of DUX4 Expression in Facioscapulohumeral Muscular Dystrophy and Possible Treatments

E Duranti, C Villa - International Journal of Molecular Sciences, 2023 - mdpi.com
Facioscapulohumeral muscular dystrophy (FSHD) represents the third most common form of
muscular dystrophy and is characterized by muscle weakness and atrophy. FSHD is caused …

265th ENMC international workshop: Muscle imaging in Facioscapulohumeral Muscular Dystrophy (FSHD): Relevance for clinical trials. 22–24 April 2022, Hoofddorp …

M Monforte, S Attarian, J Vissing, J Diaz-Manera… - Neuromuscular …, 2023 - Elsevier
On 22–24 April 2022 the 265th ENMC International Workshop on “Muscle Imaging in
Facioscapulohumeral Muscular Dystrophy (FSHD): relevance for clinical trials” took place as …

Three‐dimensional quantitative muscle ultrasound in patients with facioscapulohumeral dystrophy and myotonic dystrophy

L de Jong, A Greco, A Nikolaev, G Weijers… - Muscle & …, 2023 - Wiley Online Library
Abstract Introduction/Aims Ultrasound imaging of muscle tissue conventionally results in two‐
dimensional sampling of tissue. For heterogeneously affected muscles, a sampling error …